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Title: 1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists. Author: Sherrill RG, Berman JM, Birkemo L, Croom DK, Dezube M, Ervin GN, Grizzle MK, James MK, Johnson MF, Queen KL, Rimele TJ, Vanmiddlesworth F, Sugg EE. Journal: Bioorg Med Chem Lett; 2001 May 07; 11(9):1145-8. PubMed ID: 11354363. Abstract: A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satiety following intraperitoneal administration in a rat feeding assay was demonstrated.[Abstract] [Full Text] [Related] [New Search]