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  • Title: Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.
    Author: Schumann P, Collot V, Hommet Y, Gsell W, Dauphin F, Sopkova J, MacKenzie ET, Duval D, Boulouard M, Rault S.
    Journal: Bioorg Med Chem Lett; 2001 May 07; 11(9):1153-6. PubMed ID: 11354365.
    Abstract:
    The synthesis and pharmacological evaluation of methoxyindazoles as new inhibitors of neuronal nitric oxide synthase are presented. The 7-methoxyindazole, although less potent than 7-NI, is the most active compound of the series in an in vitro enzymatic assay of neuronal nitric oxide synthase activity. This result shows that the nitro-substitution is not indispensable to the biological activity of the indazole ring. 7-Methoxyindazole possesses in vivo NOS inhibitory as well and related antinociceptive properties.
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