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  • Title: Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.
    Author: Mokrosz MJ, Charakchieva-Minol S, Kozioł A, Kłodzińska A, Chojnacka-Wójcik E.
    Journal: Bioorg Med Chem Lett; 2001 May 07; 11(9):1229-31. PubMed ID: 11354383.
    Abstract:
    Several 1,4-disubstituted arylpiperazine derivatives of 3-arylideneindolin-2(1H)-one (Z and E isomers) were tested for their 5-HT1A and 5-HT2A receptor activity in vitro and in vivo. It was shown that introduction of 3-arylidene substituents to indolin-2(1H)-one moiety allowed to change the mixed 5-HT1A/5-HT2A receptor ligands to 5-HT2A ones with antagonistic in vivo activity.
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