These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Regulatory domain of protein stability of human P51/TAP63, a P53 homologue.
    Author: Osada M, Inaba R, Shinohara H, Hagiwara M, Nakamura M, Ikawa Y.
    Journal: Biochem Biophys Res Commun; 2001 May 25; 283(5):1135-41. PubMed ID: 11355891.
    Abstract:
    The amino terminal of human P51/TAp63, a P53 homologue, possesses a transactivation domain involved in the activation of its target genes by binding to DNA elements responsive to the p53 protein family. Using a series of amino terminal deletions, the transactivation domain was mapped between amino acid residues 50 to 69. This domain also regulates protein stability in a proteasome-dependent manner, and Ser51 and Ser68 were found to be essential for this stability. Our results suggest that P51 activity is greatly affected by protein stability.
    [Abstract] [Full Text] [Related] [New Search]