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  • Title: Systemic and local secretions of cytokines and nitric oxide in massive bowel resected rats with or without small bowel segment reversal.
    Author: Lo HC, Tsai FA, Lin SC, Wang HF.
    Journal: Cytokine; 2001 Apr 21; 14(2):112-20. PubMed ID: 11356012.
    Abstract:
    Our previous study suggested that small bowel segment reversal stimulates jejunal hyperplasia, but that the elevated serum interleukin (IL-)6 eliminates whole-body anabolism in massive bowel resected rats. The aim of this study was to investigate systemic and local secretions of cytokines and nitric oxide (NO) in relation to whole-body and tissue responses in rats that underwent massive bowel resection with small bowel segment reversal. Seventy percent small bowel resection was performed in Wistar rats with (REV) or without (CON) a 5 cm reversed small bowel segment. Sham operation (SHAM) was performed on a third group of rats. Twelve days after surgery the REV group had significantly lower weight gain and greater serum levels of NO, IL-2 and IL-6 than the CON and SHAM groups. The weights of the livers in the REV and CON groups were significantly heavier, but these groups had lower levels of protein, tumour-necrosis factor-alpha, IL-2 and IL-6 than the SHAM group. The cecum weights of the REV group were significantly higher with increased protein and NO levels, but decreased IL-6 levels compared with the CON and SHAM groups. In the proximal small intestine the REV group had significantly increased protein levels and mucosal dry weights, but decreased interferon-gamma and IL-2 compared with the CON and SHAM groups. Our results suggested that cytokines and NO may have endocrine and paracrine/autocrine actions in regulating whole-body and tissue responses.
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