These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Role of the Bloom's syndrome helicase in maintenance of genome stability.
    Author: Hickson ID, Davies SL, Li JL, Levitt NC, Mohaghegh P, North PS, Wu L.
    Journal: Biochem Soc Trans; 2001 May; 29(Pt 2):201-4. PubMed ID: 11356154.
    Abstract:
    The RecQ family of DNA helicases has members in all organisms analysed. In humans, defects in three family members are associated with disease conditions: BLM is defective in Bloom's syndrome, WRN in Werner's syndrome and RTS in Rothmund-Thomson syndrome. In each case, cells from affected individuals show inherent genomic instability. The focus of our work is the Bloom's syndrome gene and its product, BLM. Here, we review the latest information concerning the roles of BLM in the maintenance of genome integrity.
    [Abstract] [Full Text] [Related] [New Search]