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  • Title: [The GDNF family: from neurotrophic factors to oncogenesis].
    Author: Poteriaev DA, Saarma M.
    Journal: Mol Biol (Mosk); 2001; 35(2):309-20. PubMed ID: 11357413.
    Abstract:
    The structure and in vivo functions of the glial cell-derived neurotrophic factor (GDNF) family ligands (GFLs) and their high-affinity receptors are considered. These proteins play an important role in the development of the nervous system, morphogenesis of the kidneys, and in regulation of spermatogenesis. Tyrosine kinase Ret is a receptor component common for all GFLs. Its role in multiple endocrine neoplasia type 2 (MEN2) is discussed.
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