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  • Title: Sign of Leser-Trélat associated with adenocarcinoma of the rectum.
    Author: Ginarte M, Sánchez-Aguilar D, Toribio J.
    Journal: Eur J Dermatol; 2001; 11(3):251-3. PubMed ID: 11358736.
    Abstract:
    The acute onset and/or rapid increase in size and number of multiple seborrheic keratoses associated with internal malignancy is called sign of Leser-Trélat. Although some authors reject its existence, there are more than 80 well-documented case reports in the literature. Here, we report a 75-year-old man who presented with abrupt appearance of multiple seborrheic keratoses without any suspicious symptom of cancer. The screening for malignant neoplasms let us detect a rectal adenocarcinoma that was in a curative stage. This case-report illustrates a true sign of Leser-Trélat, and proves that these patients must be appropriately investigated for underlying malignancy.
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