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  • Title: Is the fluoride concentration limit of 1,500 ppm in cosmetics (EU guideline) still up-to-date?
    Author: Bloch-Zupan A.
    Journal: Caries Res; 2001; 35 Suppl 1():22-5. PubMed ID: 11359053.
    Abstract:
    The 1,500 ppm fluoride (F(-)) concentration limit set up for European cosmetic toothpaste needs to be considered in terms of effectiveness and toxicity. There is clear evidence for a dose-response relationship between F(-) concentration and caries-preventive effect (25-30% caries reduction achieved with a 1,000 ppm F(-) dentifrice). Clinical significance of higher F(-) concentration has not been totally proven. Low F(-) toothpastes (<500 ppm F(-)) have been marketed to reduce F(-) ingestion by young children in order to minimize the risk of dental fluorosis. Their effectiveness is, however, unclear. Fluoride intake and caries risk assessment should be performed by dental professionals and prescription of topical fluoride should be adjusted individually.
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