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  • Title: Risk factors for endoleak and the evidence for stent-graft oversizing in patients undergoing endovascular aneurysm repair.
    Author: Mohan IV, Laheij RJ, Harris PL, EUROSTAR COLLABORATORS.
    Journal: Eur J Vasc Endovasc Surg; 2001 Apr; 21(4):344-9. PubMed ID: 11359336.
    Abstract:
    OBJECTIVES: the aim of this study was to assess the relationship between patient factors, the anatomy of the proximal aneurysm neck; the type of endovascular graft; and the consequences of graft/neck size mismatch and the occurrence of proximal endoleak. Design multicentre clinical study. MATERIALS: of a total of 2194 patients, 2146 underwent successful endovascular repair of infra-renal abdominal aortic aneurysms (AAA). METHODS: endoleaks were identified by radiological imaging immediately after completion of the procedure as per study protocols. Clinical and anatomical features of AAA in patients with endoleak were compared to patients without endoleak and data were analysed using the Chi-square test. A multivariate logistic regression model was constructed by selecting variables found to be significantly associated with complications in a univariate analysis. RESULTS: intra-operative endoleak was observed in 16.7% overall, and 3.3% were noted to have proximal endoleak. Aneurysm size larger than 60 mm (p =0.004), ex-smokers ( p =0.005) and age over 75 years ( p =0.01) were independently associated with endoleak of all types. Univariate and multivariate analysis revealed correlation between proximal endoleak and (i) diameter of the aneurysm neck-proximal (D2a), middle (D2b), distal (D2c), at all levels (p <0.005); (ii) proximal aortic neck length ( p =0.0001); (iii) aortic device diameter ( p =0.0024). No correlation was identified for angulation and form of the aortic neck. A model of the frequency of proximal endoleak, in relation to the ratio of the aortic device diameter to the distal aortic neck diameter, revealed that endoleak decreased when the aortic device diameter became oversized by more than 10% and confidence intervals remained tight for up to and over 20% oversize.
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