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  • Title: [Changes of free radicals in fetal rats brain and liver following intrauterine fetal distress].
    Author: Song W, Han Y, Shang T.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 1999 Aug; 34(8):473-5. PubMed ID: 11360597.
    Abstract:
    OBJECTIVE: To analysis the effect of superoxide dismutase (SOD) and malondialdehyde (MDA) on different organs in intrauterine fetal distress. METHODS: The times of clamping uterine artery in A, B, C groups were 5, 10, 20 minites respectively. By clamping the matenal uterine vessels, we made the model of fetal rat distress. Slam group (13 pups) was used as control. After clamping 10 minutes, Group D (11 pups) was reperfused 5 minutes, and E (8 pups) 20 minutes. We measured the level of SOD and MDA in fetal brains and livers. RESULTS: The activity of cerebral SOD in group B and C decreased significantly than that of control (P < 0.05, P < 0.01). MDA in group C increased significantly than that of control (P < 0.05). As for liver, only SOD in group C decreased significantly (P < 0.05). In that of reperfusion group, only in group E, cerebral SOD and MDA changed significantly (P < 0.01, < 0.05), livers SOD decreased significantly (P < 0.05). CONCLUSION: After severe intrauterine fetal distress, changes of free radicals occurred in brains firstly, which provides the proof of early treatment for neonatal hypoxia ischemia brain damage.
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