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  • Title: Basic science and clinical trials: interview with William Paul, director of the Office of AIDS Research. Interview by John S James.
    Author: Paul W.
    Journal: AIDS Treat News; 1995 Feb 17; (no 217):1, 4-7. PubMed ID: 11362304.
    Abstract:
    William E. Paul, Director of the Office of AIDS Research (OAR) at the U.S. National Institutes of Health (NIH), responded to questions addressing public concern that his proposal for more basic AIDS research will reduce clinical trial research intended to find treatments. Dr. Paul clarified the role of small, rapid, data-intensive, exploratory human trials. He stressed the need for a balanced approach to studying HIV to better understand the mechanisms of this disease without abandoning therapeutic research. He believes that smaller, laboratory-intensive, pathogenesis trials should be part of the overall effort and that conventional grant support should fund data-intensive trials. Dr. Paul also advocates clinical investigation on humans, due to the lack of animal models, using known parameters to see how the immune system responds. As a result of limited funding, Dr. Paul believes that research usefulness should be a criteria for funding. The suggestion that management consultants be brought in to assess the effectiveness of the system used in conducting the research is questioned. Dr. Paul states that while systems management professionals are good at the development end, they are not experienced at grappling with problems in discovery. Finally, Dr. Paul indicates that OAR's role is recognizing where the opportunities lie and finding ways of putting the resources there.
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