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  • Title: Advances in the treatment of CMV.
    Author: Cheng B.
    Journal: PI Perspect; 1995 May; (no 16):12-3. PubMed ID: 11362420.
    Abstract:
    Research on new methods for treating and preventing CMV retinitis has provided advances in not only controlling CMV, but also improving patient quality of life. Studies of ocular CMV implants suggest that their use greatly extends the durability of treatment, resisting further retinitis in the infected eye two to three times longer than currently available therapies. Research so far has not shown that CMV retinitis spreads to the unaffected eye. Another drug, HPMPC, requires much less frequent IV infusions, however, unlike implants, it does not eliminate need for them. Comparisons of quality-of-life issues involving this drug are difficult to assess, and no direct comparisons of long-term effects of this approach versus use of implants have been made. The combination of ganciclovir and foscarnet produces a significantly longer time to progression to retinitis compared to those who received either ganciclovir or foscarnet alone. No survival benefit has been shown.
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