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  • Title: Major study shows AZT monotherapy inferior.
    Author: James JS.
    Journal: AIDS Treat News; 1995 Sep 29; (no 231):3-4. PubMed ID: 11362867.
    Abstract:
    A major government study has found that AZT alone is inferior to AZT plus ddI or AZT plus ddC combination therapy, or to ddI therapy alone, in patients starting with a CD4 count between 200 and 500. Over 2,000 patients were enrolled in a randomized trial that lasted two years. Patients who did not do well on the therapy were switched to a different study. Results of the study were analyzed differently for patients that had previously taken antivirals as opposed to those that were antiretroviral-naive. AZT alone performed worse than combinations in both of these groups. Selected patients also had results analyzed in terms of change in viral load; AZT alone proved to be the least effective in lowering viral load when compared to the combinations.
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