These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Protease inhibitor update: treatment combination strategies.
    Author: Mascolini M.
    Journal: AIDS Treat News; 1996 Jan 19; (no 239):3. PubMed ID: 11363085.
    Abstract:
    Major pharmaceutical manufacturers have agreed that even the most potent protease inhibitors will work more effectively in combination with nucleoside analogs. Protease inhibitors also may be more effective when combined together. A Merck trial indicated that half of the participants taking both AZT and indinavir had viral load reductions below the limit of detection, compared to only thirty percent who used either of the drugs alone. Abbott reported similar findings with ritonavir, AZT, and ddC. Glaxo's protease inhibitor, VX-478, has not yet been tested in combination with other drugs. To date, saquinavir is the only protease inhibitor to be approved by the Food and Drug Administration (FDA).
    [Abstract] [Full Text] [Related] [New Search]