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  • Title: Protease inhibitors: implications for HIV research and treatment.
    Author: Churchill SA.
    Journal: J Int Assoc Physicians AIDS Care; 1996 Jan; 2(1):13-8. PubMed ID: 11363325.
    Abstract:
    Much of the information presented at the Fifth European Conference on Clinical Aspects and Treatment of HIV Infection dealt with HIV protease inhibitors. Pharmacologic, pharmacokinetic, and therapeutic aspects of ritonavir, saquinavir, and indinavir, given individually, were assessed by both viral load testing and CD4 counts. Ritonavir, used in combination with ddC and AZT, reduced HIV RNA and increased CD4 count, with minimal adverse effects. The development of HIV resistance and cross resistance to these protease inhibitors was discussed, with an examination of the number of mutations needed to render the HIV virus resistant. When to begin treatment with these drugs was also a topic of discussion.
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