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  • Title: ACTG 343: three drugs better than two for maintaining HIV suppression.
    Author: Bowersox J.
    Journal: NIAID AIDS Agenda; 1998 Mar; ():1-2, 10-1. PubMed ID: 11365088.
    Abstract:
    Studies indicate that patients who have responded well to intensive antiretroviral therapy should continue their current treatment regimen rather than switch to less intensive therapy during the maintenance phase. Data from ACTG 343, a study to determine the sustaining of HIV suppression with fewer drugs, reveals that less intensive antiviral maintenance therapies were less effective than continuation of the triple-drug regimen; findings were statistically significant. Viral load rebound was far more prevalent in one- or two-drug maintenance regimens than in the triple-drug therapies. Further, data show viral load rebound more likely when the patient's viral load had not gone below 200 copies of HIV RNA/ml within four weeks of initiating triple-therapy. Findings from other multiple-drug trials and immune stimulating reactions from vaccine trials are summarized.
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