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  • Title: Reevaluating initial therapy.
    Author: Cadman J.
    Journal: GMHC Treat Issues; 1998 Feb; 12(2):1-5. PubMed ID: 11365217.
    Abstract:
    Numerous treatment options are available for antiretroviral-naive patients and the initial sequence of drugs prescribed for them can have consequences on future treatments. Physicians need to make wise decisions when prescribing medications to prevent the development of cross-resistance to other medications. Currently, d4T and AZT are common initial therapies. Results of the ACTG 306 trials, evaluating several combinations for both short-term and long-term effectiveness, are described. The choice of drugs for any treatment regimen must also consider convenience and tolerability. Whichever nucleoside analogs are chosen will frequently be combined with protease inhibitors or other drugs. Food restrictions, drug interactions, dosing requirements, and side effects may make a particular regimen less desirable.
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