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Title: Indinavir--study highlights importance of CD4+ counts over viral load. Journal: TreatmentUpdate; 1998 Nov; 10(9):2-3. PubMed ID: 11365923. Abstract: Long-term combination therapy with protease inhibitors has often led to increased CD4+ cell counts and decreased viral loads, which can contribute to overall clinical improvement in patients. However, individual results can vary widely. A French study of 162 patients is detailed in which patients received Indinavir in combination with 2 nucleoside analogues. Among the participants, some experienced increased CD4+ counts without a significant drop in viral load, while others experienced a significant decrease in viral load without an increase in their CD4+ counts. Study details and results are reported. Results from this study suggest that increasing CD4+ counts may provide a "protective effect" against life-threatening infections.[Abstract] [Full Text] [Related] [New Search]