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  • Title: Promising findings from the PETRA study of perinatal transmission.
    Author: Hanna L.
    Journal: BETA; 1999 Apr; 12(2):19. PubMed ID: 11366687.
    Abstract:
    Preliminary results from the PErinatal TRAnsmission (PETRA) study at the 6th CROI presented the "shortest effective regimen ever". The study of 2,000 women and their infants was conducted in South Africa, Uganda, and Tanzania, and seeks a short-course regimen which could be used in poorer countries. Three combinations of AZT and 3TC were evaluated in 1,792 participants, and mothers and babies were evaluated at six weeks postpartum. Results are still being evaluated, since breast-feeding is a significant transmitter of HIV and perinatal transmission is not ruled out until the child is 18 months old. Results show that postpartum treatment is crucial and that only one or two doses of AZT/3TC for the mother during labor and one week postpartum. This combination for the newborn significantly reduces perinatal transmission. The study is sponsored by UNAIDS and is designed to develop a range of treatment and prevention options for women in developing countries.
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