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  • Title: Single-dose Nevirapine during pregnancy.
    Author: Sax PE.
    Journal: AIDS Clin Care; 1999 Oct; 11(10):84-5. PubMed ID: 11366708.
    Abstract:
    The recommended three-part antiretroviral therapy featuring AZT to reduce perinatal transmission is not feasible in developing countries because of cost and other barriers to health care delivery. The HIVNET 012 study in Uganda shows that single-dose Nevirapine for the woman in labor followed by a single dose for the infant is more effective in reducing the risk of transmission than the AZT regimen. A cost-effectiveness study using data from HIVNET 012 shows that treatment with Nevirapine costs much less than the $50 threshold widely used for public health intervention in poorer countries. Though studies on the long-term safety and efficacy of the Nevirapine therapy have not been done, Nevirapine therapy appears to be the best current method for the prevention of perinatal transmission of HIV.
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