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  • Title: [Retrospective analysis of 18 cases with agranulocytosis induced by antithyroid drugs].
    Author: Dai W, Zhang J, Zhan Z, Xu B, Jin H.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1998 Jun; 20(3):226-9. PubMed ID: 11367711.
    Abstract:
    OBJECTIVE: To analyse the routine WBC count's effect on predicting antithyroid drugs-induced agranulocytosis developing and risk factors of antithyroid drugs-induced agranulocytosis. METHODS: Retrospective analysis of 18 Graves' cases with agranulocytosis induced by antithyroid drugs during 1984-1995. RESULTS AND CONCLUSIONS: Most of antithyroid drugs-induced agranulocytosis happens 2-12 weeks after the administration of antithyroid drug, and are related with the drug's doses. Some agranulocytosis happens abruptly, routine WBC and granulocyte count can not predict some agranulocytosis developing. Fever and throat sore are the intitial symptoms of agranulocytosis, if it happens, the WBC and granulocyte count must be checked immediately. The treatment of granulocyte-macrophage colony stimulating factor is effective, the corticosteroid therapy seems not to be useful for the recovery of granulocyte count.
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