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  • Title: [The observation on infection of trasgenic mice (PVR Tg21) with polioviruses type 3].
    Author: Guo R, Chen S, Luo Q, Wang Q.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1998 Feb; 20(1):70-5. PubMed ID: 11367738.
    Abstract:
    OBJECTIVE: To test and verify whether PVR Tg21 transgenic mice can be used as an animal model or not. METHODS: PVR Tg21 transgenic mice were infected with 3 poliovirus strains with different neurovirulence intraspinally. RESULTS: All the mice showed clinical paralysis with characteristic lesions in neurons. The symptoms varied with different potency of virus. The onset of clinical paralysis time for inoculated mice were approximately 2 days with Leon virus, 5 days with Sabin strain, and 4 days with Vaccine-321. More than 90% of mice inoculated with Leon strain died within 3 days after clinical paralysis and only 35% mice inoculated with Sabin-3 died at average of 6 days, and the PD50 are 10(1.1), 10(2.6), and 10(4.97) TCID50 and LD50 are 10(1.1), 10(3.33) and 10(5.33) TCID50, respectively. Different virus inoculated intraspinally caused different histopathological lesions. CONCLUSIONS: The PVR Tg21 transgenic mice could be a new animal model for neurovirulent evaluation of poliovaccines and epidemiological surveillance.
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