These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effect of SNP on KCa of resistance vascular smooth muscle cell membrane in SHRsp].
    Author: Zheng Y, Wang G, Bao G, Qu J, Wang X.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1998 Feb; 20(1):8-16. PubMed ID: 11367740.
    Abstract:
    OBJECTIVE: To investigate the effect of sodium nitroprusside (SNP) on calcium activated potassium channels (KCa) of mesenteric arterial A4-A5 branches resistence vascular smooth muscle cell membrane in Stroke-prone Spontaneously Hypertensive Rats (SHRsp) and its normotensive control WKY rats. METHODS: Cell-attached patch clamp technique was used. RESULTS: It was found that SNP could activate the KCa of the resistance vascular smooth muscle in both SHRsp and WKY. Under the same dose of SNP (1 nmol/L), the conductance and channel current amplitude etc. of the activated KCa in SHRsp were smaller than that in WKY rats. Given the same dose of 8-Br-cGMP (10 mumol/L), the cGMP activation of SHRsp KCa was less potentiated than that of WKY, appeared very similar to SNP/NO activation. CONCLUSIONS: The results suggested the KCa of hypertensive resistance vascular smooth muscle membrane appearing weaker response to relaxing factor EDRF/NO.
    [Abstract] [Full Text] [Related] [New Search]