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  • Title: Presence of serotonin in the rat vas deferens: its influence on contractile responses.
    Author: Fuenmayor L, Gomez J, Campos HA, Romero E.
    Journal: Neuroscience; 1976 Jun; 1(3):197-203. PubMed ID: 11370231.
    Abstract:
    Serotonin has been detected in the rat vas deferens. Increase in the serotonin concentration by exposure of the rat vas deferens to L-tryptophan occurs in vitro. p-chlorophenylalanine partly blocks the increase in serotonin concentration induced by tryptophan in vitro but not in vivo. Chronic sympathetic denervation induces an increase in 5-HT concentration. Responses of the vas deferens to transmural stimulation are depressed by pretreatment of rats with p-chlorophenylalanine, and the depression is reversed by incubation in vitro with 5-hydroxytryptophan or serotonin. Serotonin can enhance the response to transmural stimulation at low concentrations but has no effect at higher concentrations. Physostigmine-induced enhancement of the response to stimulation is depressed only by higher concentrations of serotonin. The results raise the question whether endogenous serotonin can act as a modulator of neurotransmission in the rat vas deferens. Various experiments were conducted to evaluate the influence of serotonin (5-HT) on contractile responses of the rat vas deferens in vitro and in vivo. In vitro exposure of the vas deferens to L-tryptophan increased serotonin concentration. p-Chlorophenylalanine partially blocked this increase in vitro but not in vivo. The concentration of 5-HT was also increased by chronic sympathetic denervation. Pretreatment with p-chlorophenylalanine depressed the contractile response to transmural stimulation, while incubation with 5-hydroxytryptophan or serotonin reversed this effect. Low, but not high, concentrations of serotonin enhanced the response to transmural stimulation. However, only high concentrations of serotonin depressed the physostigmine-induced enhancement of the contractile response to transmural stimulation. The results suggest that endogenous serotonin may modulate neurotransmission in the rat vas deferens.
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