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  • Title: S-phase dependent cytogenetic toxicity of 5-fluorouracil in bone marrow cells of mice.
    Author: Choudhury RC, Misra S, Jagdale MB, Palo AK.
    Journal: J Exp Clin Cancer Res; 2001 Mar; 20(1):57-62. PubMed ID: 11370831.
    Abstract:
    The in vivo cytogenetic toxicity of three different doses (5,10 and 15 mg/kg) of 5-fluorouracil (5-FU) (in Fluracil) was assessed in bone marrow cells of mice. At 24 hrs post-treatment the induced chromosomal aberrations, mostly chromatid breaks and fragments, by all the three different concentrations of 5-FU were found statistically significant. However, mitotic index study at 24 hrs post-treatment indicated it as nonmitotoxic. At 30 hrs posttreatment, all the three doses of 5-FU induced a statistically significant number of micronuclei per thousand polychromatic erythrocytes. This indicated 5-FU as nonmitotoxic but highly clastogenic in bone marrow cells of mice.
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