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  • Title: [Effects of 3-N-butylphthalide on cortical calcineurin and calpain activities in focal cerebral ischemia rats].
    Author: Dong GX, Feng YP.
    Journal: Yao Xue Xue Bao; 2000 Oct; 35(10):790-2. PubMed ID: 11372450.
    Abstract:
    AIM: To explore if the inhibitory effect of 3-n-butylphthalide(NBP) on apoptosis induced by transient focal cerebral ischemia in rats is relevant to cortical calcineurin and calpain activities. METHODS: The model of cerebral ischemia-reperfusion was used. The activities of the two enzymes were measured by using biochemical methods. RESULTS: DL-NBP and D-NBP 20 mg.kg-1 were found to significantly reduce ischemia ipsilateral cortical calcineurin and calpain activities. However, L-NBP 20 mg.kg-1 showed no obvious effect. CONCLUSION: The anti-apoptotic effect of NBP may be relevant to its inhibition of calcineurin and calpain activities in focal cerebral ischemia rats.
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