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  • Title: 17 beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids.
    Author: Chen J, Xu W, Jiang H.
    Journal: Anesth Analg; 2001 Jun; 92(6):1520-3. PubMed ID: 11375837.
    Abstract:
    We studied the effect of 17 beta-estradiol on ischemia-induced increases in extracellular amino acids (aspartate, glutamate, glycine, and taurine) in the gerbil hippocampal CA1 region by a microdialysis-high-performance liquid chromatography system in vivo. Transient forebrain ischemia for 3 min produced a marked accumulation of aspartate, glutamate, taurine, and glycine (498%, 410%, 266%, and 178%, respectively). 17 beta-estradiol reduced the increase of aspartate and glutamate by 57% and 53% of the peak values. This finding suggests that 17 beta-estradiol may protect neurons against ischemic damage by attenuating the ischemia-induced increase in extracellular excitatory amino acids.
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