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  • Title: Biofilm formation by gram-negative bacteria on central venous catheter connectors: effect of conditioning films in a laboratory model.
    Author: Murga R, Miller JM, Donlan RM.
    Journal: J Clin Microbiol; 2001 Jun; 39(6):2294-7. PubMed ID: 11376074.
    Abstract:
    Human blood components have been shown to enhance biofilm formation by gram-positive bacteria. We investigated the effect of human blood on biofilm formation on the inner lumen of needleless central venous catheter connectors by several gram-negative bacteria, specifically Enterobacter cloacae, Pseudomonas aeruginosa, and Pantoea agglomerans. Results suggest that a conditioning film of blood components promotes biofilm formation by these organisms in an in vitro system.
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