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  • Title: Interaction between angiotensin IV and adenosine A(1) receptor related drugs in passive avoidance conditioning in rats.
    Author: Tchekalarova J, Kambourova T, Georgiev V.
    Journal: Behav Brain Res; 2001 Aug 27; 123(1):113-6. PubMed ID: 11377734.
    Abstract:
    The functional interaction between ANG (3--8) (ANG IV) and adenosine A(1) receptor related drugs in passive avoidance (step-through) task in rats was studied in Wistar rats. ANG IV exerted dose-dependent (inverted-U) improvement of the retention while sarilesin (an angiotensin II analog) impaired this effect. Co-administration of theophylline and ANG IV, both in ineffective doses, enhanced the retention. The selective adenosine A(1) receptor agonist cyclopentyladenosine (CPA) attenuated ANG IV-induced memory enhancement.
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