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  • Title: Anti-inflammatory activity of lupeol and lupeol linoleate in rats.
    Author: Geetha T, Varalakshmi P.
    Journal: J Ethnopharmacol; 2001 Jun; 76(1):77-80. PubMed ID: 11378285.
    Abstract:
    Two pentacyclic triterpenes, namely lupeol and lupeol linoleate, were investigated for their anti-inflammatory, antinociceptive, anti-pyretic and ulcerogenic properties in comparison with the commonly used non-steroidal anti-inflammatory drug, indomethacin in rats. Lupeol, lupeol linoleate and indomethacin showed a reduction in paw swelling by 39, 58 and 35%, respectively, in adjuvant arthritis. Triterpenes were devoid of any antinociceptive, anti-pyretic and ulcerogenic actions. However, indomethacin exhibited a positive response to these properties. These results suggest that the mechanism of action of triterpenes is different from the non-steroidal anti-inflammatory drug.
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