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  • Title: Rat liver responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia.
    Author: de Souza HM, Borba-Murad GR, Ceddia RB, Curi R, Vardanega-Peicher M, Bazotte RB.
    Journal: Braz J Med Biol Res; 2001 Jun; 34(6):771-7. PubMed ID: 11378667.
    Abstract:
    Hepatic responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia was investigated. For this purpose, livers were perfused with a saturating concentration of 2 mM glycerol, 5 mM L-alanine or 5 mM L-glutamine as gluconeogenic substrates. All experiments were performed 1 h after an ip injection of saline (CN group) or 1 IU/kg of insulin (IN group). The IN group showed higher (P<0.05) hepatic glucose production from glycerol, L-alanine and L-glutamine and higher (P<0.05) production of L-lactate, pyruvate and urea from L-alanine and L-glutamine. In addition, ip injection of 100 mg/kg glycerol, L-alanine and L-glutamine promoted glucose recovery. The results indicate that the hepatic capacity to produce glucose from gluconeogenic precursors was increased during insulin-induced hypoglycemia.
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