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  • Title: Non-transferrin-bound iron during allogeneic stem cell transplantation.
    Author: Sahlstedt L, Ebeling F, von Bonsdorff L, Parkkinen J, Ruutu T.
    Journal: Br J Haematol; 2001 Jun; 113(3):836-8. PubMed ID: 11380478.
    Abstract:
    Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications. The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was followed for 20 d. The transferrin saturation reached 99% on d -4 and remained > 80% thereafter. NTBI, measured as bleomycin-detectable iron, was detected for 6-18 d in all patients with a peak on d -4. High transferrin saturation levels were associated with the appearance of NTBI with a threshold at 80% saturation. Prevention of the potential deleterious effects of NTBI might reduce transplantation-related morbidity.
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