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  • Title: Preparation, quality control and clinical acceptance of labeled Macrotec.
    Author: Clayton BD, Ice RD, Beierwaltes WH.
    Journal: Radiology; 1975 Jul; 116(1):223-5. PubMed ID: 1138275.
    Abstract:
    Thirty minutes after reconstitution, radiochemical purity determinations of the lung-scanning agent Macrotec (99m-Tc-MAA) indicated 95-100% technetium labeling: 76% of the particles had a mean diameter of 10-50 mu. Rat tissue distribution studies indicated lung uptake of 98% at 15 minutes. The biological half-life in the lung was 8.3 hours. In 12 patients requiring emergency lung scans, 9 scans were rated excellent. No liver, spleen or thyroid uptake or adverse reactions were noted.
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