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  • Title: Midtrimester pregnancy interruption and the placental progesterone levels.
    Author: Aleem FA, Schulman H.
    Journal: Prostaglandins; 1975 Mar; 9(3):495-500. PubMed ID: 1138306.
    Abstract:
    Placental progesterone contents were studied in 10 patients therapeutically aborted at midtrimester by intraamniotic infusions of hypertonic saline, and from 14 patients (12-20 weeks) aborted by intraamniotic instillation of prostaglandin F-2alpha. The mean S.E. of the progesterone was 1.99 plus or minus 0.07 ug/g. placental tissue in the first group, while with prostaglandin abortion the placental progesterone was 1.45 plus or minus 0.08 ug/g. tissue, which is significantly lower than the results in the first group (P equals 0.001). The possible mechanism of action of prostaglandin as an effective abortifacient is discussed. Placental progesterone (P) levels in patients aborted at midtrimester by intraamniotic instillation of prostaglandin (PG) F2 alpha and by hypertonic saline were compared and correlated to abortion-instillation intervals. 10 patients were instilled with hypertonic saline at midtrimester and 14 patients (12-20 weeks) were instilled with hypertonic saline. PGF2 alpha group average abortion interval was 16.5 + or - 2.1 hours, and the abortion time for saline was 36 + or - 3.4 hours. Placental P levels in the 14 patients aborted with PGF2 alpha ranged from .65 to 1.9 mcg/gm and the mean standard error was 1.45 + or - .09, which was significantly lower (P=.001) than the mean standard error of 1.99 + or - .07 mcg/gm of tissue for hypertonic saline infusion. 2 mechanisms of PGF2 alpha abortifacient effect are theorized: 1) PG may directly interfere with functional integrity of placenta and interrupt P synthesis, or 2) the higher uterine activity associated with PG may impair placenta function by an ischemic insult.
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