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  • Title: Prevalence of the T215Y mutation in human immunodeficiency virus type 1-infected pregnant women in a New York cohort, 1995--1999.
    Author: Sitnitskaya Y, Rochford G, Rigaud M, Essajee S, Pollack H, Krasinski K, Borkowsky W.
    Journal: Clin Infect Dis; 2001 Jul 01; 33(1):e3-7. PubMed ID: 11389511.
    Abstract:
    From 1997 through 1999, the prevalence of the zidovudine resistance mutation T215Y was 9.7% among pregnant women, and the human immunodeficiency virus type 1 (HIV-1) load in those with resistant virus was higher than that measured in women with wild-type HIV-1. All mutations were noted in women with zidovudine experience, which suggests that monotherapy may not be adequate prophylaxis for vertical transmission of HIV-1 infection in the current era.
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