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  • Title: Cell surface human alpha-L-fucosidase.
    Author: Cordero OJ, Merino A, Páez de la Cadena M, Bugía B, Nogueira M, Viñuela JE, Martínez-Zorzano VS, de Carlos A, Rodríguez-Berrocal FJ.
    Journal: Eur J Biochem; 2001 Jun; 268(11):3321-31. PubMed ID: 11389735.
    Abstract:
    The acid alpha-L-fucosidase is usually found as a soluble component of lysosomes where fucoglycoconjugates are degraded. In the present investigation, we have demonstrated the existence of a cell surface protein with enzymatic alpha-L-fucosidase activity that crossreacts specifically with a rabbit anti-(alpha-L-fucosidase) Ig. By different approaches, this alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity, was detected in all the tested human cells (hemopoietic, epithelial, mesenchymal). Two bands of approximately 43-49 kDa were observed, although theoretical data support the possibility of having the same genetic origin that the known 50 to 55-kDa Mr alpha-L-fucosidase. We speculate about an alternative traffic pathway for the plasma membrane alpha-L-fucosidase to work on the rapid turnover of glycoproteins.
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