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  • Title: Skeletal and cardiac muscle contractile activation: tropomyosin "rocks and rolls".
    Author: Gordon AM, Regnier M, Homsher E.
    Journal: News Physiol Sci; 2001 Apr; 16():49-55. PubMed ID: 11390948.
    Abstract:
    Changes in thin filament structure induced by Ca(2+) binding to troponin and subsequent strong cross-bridge binding regulate additional strong cross-bridge attachment, force development, and dependence of force on sarcomere length in skeletal and cardiac muscle. Variations in activation properties account for functional differences between these muscle types.
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