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  • Title: [The effect of iron and zinc on lead absorption in the tunica mucosa of various parts of rat small intestine ].
    Author: Luhovs'kyĭ SP.
    Journal: Fiziol Zh (1994); 2001; 47(2):41-5. PubMed ID: 11392113.
    Abstract:
    Kuring experiments on turned out sacs models of duodenum, jejunum and ileum of rats the differences in levels of exogenous Pb2+ absorption were revealed. The most values were in tunica mucosa (TM) of duodenum and jejunum. Pb2+ absorption was influenced by previous exposure to trace elements (TE) of Fe2+ (0.79 mmole/100 g) and Zn2+ (0.36 mmole/100 g) having been inducted to stomach. TE due to their physical and chemical properties reduced Pb2+ absorption in different parts of intestine TM on the average by 14-49%. It was determined that TE prevented Pb2+ absorption in TM of intestine more effectively during combined introduction compared to isolated one (accordingly 42% in duodenum, 43% in ileum and 29% in jejunum). Reducing Pb+ absorption is explained by probable substrates competition for active centers of their binding and transfer to TM to intestine.
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