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  • Title: [Neonatal screening for sickle cell anemia: evaluation of a five-year experience in an area of northern Paris].
    Author: Ducrocq R, Benkerrou M, Brahimi L, Belloy M, Briard ML, Vilmer E, Elion J.
    Journal: Arch Pediatr; 2001 May; 8(5):474-80. PubMed ID: 11396106.
    Abstract:
    UNLABELLED: We report a five-year experience of targeted neonatal screening for sickle cell disease in the northern part of the Paris area as well as the follow-up procedure of screened patients. POPULATION: This geographic area in France is characterized by a high frequency of populations at risk for sickle cell disease. RESULTS: Among 115,480 tested newborns, 250 patients were diagnosed (frequency: 1/462). The quality of the screening was attested by the high frequency (5.34%) of newborn carriers for a hemoglobin abnormality (n = 6168). We developed an optimized strategy which avoids the majority of pitfalls (false positive and false negative responses), except for S/HPFH. More than 95% of sickle cell disease was followed, the majority by medical sickle cell disease experts from hospitals. Only two deaths were recorded during this time period. CONCLUSION: We demonstrate the efficiency of targeting the proposed methodological strategy and the follow-up of affected newborns, a major argument demonstrating the importance of newborn screening.
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