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  • Title: Antituberculous activity of norfloxacin mannich bases with isatin derivatives.
    Author: Pandeya SN, Sriram D, Yogeeswari P, Ananthan S.
    Journal: Chemotherapy; 2001; 47(4):266-9. PubMed ID: 11399863.
    Abstract:
    Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The compounds were evaluated in vitro against Mycobacterium tuberculosis H37R(v) at 12.5 microg/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower than 6.25 microg/ml.
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