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  • Title: [Cyclin-dependent kinase 4 inhibitor a and tumor].
    Author: Gong Z, Fu J.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2001 Jun; 18(3):219-21. PubMed ID: 11402455.
    Abstract:
    INK4a/ARF locus encodes at least two products, P16(INK4a) and P19(ARF), which are very important in controlling cell-cycle arrest and apoptosis. Many human cancers have been found to be highly related to the mutations at this locus. Here is a review of its structure, function and role in tumor suppression.
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