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  • Title: The role of preoptic area and anterior hypothalamus and median raphe nucleus on thermoregulatory system in freely moving rats.
    Author: Ishiwata T, Hasegawa H, Yasumatsu M, Akano F, Yazawa T, Otokawa M, Aihara Y.
    Journal: Neurosci Lett; 2001 Jun 22; 306(1-2):126-8. PubMed ID: 11403973.
    Abstract:
    To clarify the role of the preoptic area and anterior hypothalamus (PO/AH) on thermoregulatory system and the effects of serotonergic innervation from the median raphe nucleus (MRN) on body temperature (Tb), we perfused tetrodotoxin (TTX) solution into the PO/AH or MRN by using a microdialysis technique at different ambient temperatures (5, 23 and 35 degrees C) in freely moving rats. Tb was continuously monitored by using a telemetry system. In the MRN, perfusion of TTX solution induced significant hypothermia in the normal environment, a greater decrease in Tb during cold exposure and had no effect on Tb during heat exposure. In the PO/AH, perfusion of TTX solution induced significant hyperthermia in normal environment, a greater increase in Tb during heat exposure and had no effect on Tb during cold exposure. Our results indicate that the PO/AH regulates mainly heat loss or inhibits the loci regulating heat production. Furthermore, heat production appears to be regulated by other loci receiving serotonergic innervation from the MRN.
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