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  • Title: Who is the boss in the retinoblastoma family? The point of view of Rb2/p130, the little brother.
    Author: Paggi MG, Giordano A.
    Journal: Cancer Res; 2001 Jun 15; 61(12):4651-4. PubMed ID: 11406530.
    Abstract:
    This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107. After a brief analysis of the established structural and functional similarities among the three genes, the main purpose is to critically analyze present evidence whether Rb2/p130 shares the role of a tumor suppressor. Taking into account the well-proven growth suppressive properties of Rb2/p130 and p107, we discuss the analysis of mutated or deleted forms of Rb2/p130 found in a number of human cancers. Finally, we take into consideration the data provided by the targeted disruption of each RB family gene, alone or in combination, in the mouse model.
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