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  • Title: Hepatoprotective activity of indigtone--a bioactive fraction from Indigofera tinctoria Linn.
    Author: Singh B, Saxena AK, Chandan BK, Bhardwaj V, Gupta VN, Suri OP, Handa SS.
    Journal: Phytother Res; 2001 Jun; 15(4):294-7. PubMed ID: 11406850.
    Abstract:
    A bioactive fraction, indigtone (FA), obtained by fractionation of a petroleum ether extract of the aerial parts of Indigofera tinctoria, showed significant dose related hepatoprotective activity against CCl(4) induced liver injury in rats and mice. Hexobarbitone induced 'sleeptime', zoxazolamine induced 'paralysis time', levels of transaminases, bilirubin and total protein in serum were employed as indices of liver injury. Pre and post treatment with FA significantly reversed the majority of the parameters altered by the hepatotoxin. This indicated the preventive and restorative effect of FA in the process of CCl(4) induced liver damage. The fraction possessed a high therapeutic ratio, as no mortality was observed up to a dose of 2 g/kg p.o. in mice.
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