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  • Title: Sythesis of polypeptide models of collagen.
    Author: Rapaka RS, Bhatnager RS.
    Journal: Int J Pept Protein Res; 1975; 7(2):119-28. PubMed ID: 1140884.
    Abstract:
    The synthesis of several sequential oligomer models of collagen is reported. Polytripeptides H(-Pro-Gly-Leu)n OH, H(-Pro-Gly-Phe)n OH, H(-Pro-Sar-Gly)n OH, H-(Sar-Pro-Gly-)n -OH, H(-Pro-Gly-V-AL-)N OH and H(-Gly-Val-Pro)n -oh were synthesized by the active ester method. Preliminary fractionation and mol.wt. determination showed typical gaussian distributions. Good yields were obtained in the mol.wt. range of 4,000-6,000, except in the case of H(-Pro-Sar-Gly-)n OH which yielded molecular weights over 20,000.
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