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  • Title: Inhibitory effect of lactoperoxidase-generated hypothiocyanite upon black pigmented anaerobe growth.
    Author: Fadel M, Courtois P.
    Journal: Int J Mol Med; 2001 Jul; 8(1):59-62. PubMed ID: 11408950.
    Abstract:
    This study aimed to evaluate the in vitro effect of lactoperoxidase with or without its substrates (hydrogen peroxide, thiocyanate) on the growth of 4 different black pigmented anaerobe (BPA) strains associated with the development and progress of periodontal diseases: Porphyromonas gingivalis ATCC 33277, Prevotella intermedia NCTC 9336, Prevotella loescheii ATCC 15930, and Prevotella melaninogenica NCTC 9338. A 5-min lactoperoxidase-generated OSCN--HOSCN incubation at pH 6.0, 7.0 or 8.0 resulted in a decrease of the growth rate (tested by turbidimetry in liquid cultures) of the 4 BPA strains, whilst lactoperoxidase alone actually promoted bacterial growth.
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