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  • Title: Polygraphic night sleep pattern during chronic single and multiple neuroleptic dose administration.
    Author: Jus K, Beland C, Bouchard M, Jus A, Fontaine P, Brunelle R.
    Journal: Int Pharmacopsychiatry; 1975; 10(1):58-63. PubMed ID: 1140904.
    Abstract:
    A comparison was made between the polygraphic night-sleep pattern of chronic schizophrenic patients who were receiving a single dose of neuroleptics at bedtime and between the night-sleep pattern of the same patients receiving the same amount of the same neuroleptic divided into 3-4 doses during daytime. It was shown that the single bedtime dose provoked a significant increase in the mean percentage of the NREM stage 4 and of the mean percentage of the REM state whereas the mean percentage of the NREM stage 2 was significantly decreased.
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