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  • Title: [Inhibition of voltage-activated outward delayed rectifier potassium channel currents in dorsal root ganglion neurons of rats by lead].
    Author: Xiao H, Dai X, Mao X.
    Journal: Zhonghua Yu Fang Yi Xue Za Zhi; 2001 Mar; 35(2):108-10. PubMed ID: 11413681.
    Abstract:
    OBJECTIVE: To study the effect of lead on voltage-activated outward delayed rectifier potassium channel currents in acute isolated dorsal root ganglion (DRG) neurons of adult rats. METHODS: Patch clamp technique was employed to record the whole cell of DRG in adult rats. RESULTS: In the experiments, delayed rectifier (IK) potassium currents channel was recorded and activation was voltage-dependent. The threshold concentration of lead (Pb2+) for IK was 1 mumol/L, which reduced potassium current by (8.6 +/- 0.8)%, 4 mumol/L of Pb2+ reduced the current by (38.6 +/- 6.2)%, and 8 mumol/L of Pb2+ reduced the current by (63.0 +/- 5.1)%. The action of lead was rapid and its effect would be reversed rapidly to various extent by washing. CONCLUSION: Higher outward delayed rectifier potassium channel currents, which could be reversed.
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