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  • Title: The thymus and myasthenia gravis.
    Author: Ragheb S, Lisak RP.
    Journal: Chest Surg Clin N Am; 2001 May; 11(2):311-27, x. PubMed ID: 11413758.
    Abstract:
    Self acetylcholine receptor (AchR) is targeted by a wayward immune response in myasthenia gravis (MG). The current understanding of the pathogenesis of the AChR-directed immune response is reviewed. Furthermore, the thymus is suspected of initiating and perpetuating the disease process in the majority of patients; its role as a central and peripheral lymphoid organ in MG is discussed. MG seems to result from a failure of (1) establishing tolerance to the AChR and (2) regulating the immune response.
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